Polysaccharide-Based Coating with Excellent Antibiofilm and Repeatable Antifouling-Bactericidal Properties for Treating Infected Hernia.

In recent years, the utilization of medical devices has gradually increased and implantation procedures have become common treatments. However, patients are susceptible to the risk of implant infections. This study utilized chemical grafting to immobilize polyethylenimine (QPEI) and hyaluronic acid (HA) on the surface of the mesh to improve biocompatibility while being able to achieve antifouling antimicrobial effects. From the in vitro testing, PP-PDA-Q-HA exhibited a high antibacterial ratio of 93% against S. aureus, 93% against E. coli, and 85% against C. albicans. In addition, after five rounds of antimicrobial testing, the coating continued to exhibit excellent antimicrobial properties; PP-PDA-Q-HA also inhibits the formation of bacterial biofilms. In addition, PP-PDA-Q-HA has good hemocompatibility and cytocompatibility. In vivo studies in animal implantation infection models also demonstrated the excellent antimicrobial properties of PP-PDA-Q-HA. Our study provides a promising strategy for the development of antimicrobial surface medical materials with excellent biocompatibility.

Growth characteristics of Cynodon dactylon and mechanical properties of slope with different sludge contents.

The utilization of dredged sludge can reduce environmental pollution and save land resources. To explore using sludge resources in ecological slope-protection projects, dredged sludge was incorporated into ecological slope-protection soil. Cynodon dactylon was planted to analyze the effect of sludge content on its growth. Direct-shear tests on the slope-protection soil with and without Cynodon dactylon were conducted to elaborate on the effect of sludge content, water content, and roots on the mechanical properties of the sludge-clay mixture. When the sludge content was <50%, Cynodon dactylon's growth improved with the sludge content increase, but at >50%, the sludge content's effect was meagre. As the sludge content increased, the cohesion and internal friction angle of the sludge-clay mixture without roots decreased, lowering the shear strength. The soil's cohesive force and internal friction angle follows the sequence: natural state with roots > natural state without roots > saturated state with roots > saturated state without roots. The cohesion and shear strength of the sludge-clay mixture with roots increased at first before decreasing with an increase in sludge content, optimized at 50% sludge content. Here, the ecological slope stability was the best, meaning that the optimum sludge proportion was 50%.